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pentobarbital decreases levels of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Robust CYP3A4 inducers can lessen panobinostat ranges by ~70% and produce therapy failure.pentobarbital will lower the extent or influence of vincristine liposomal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Insi